Derived from Nature. Backed by Science. Driven by Results.

MACRENE Actives is the cleanest, scientifically active and clinically proven luxury skincare brand founded by world renowned dermatologist, scientist, and textbook author Dr. Macrene Alexiades, MD PhD FAAD. The brand’s mission is to harness exceptional natural ingredients—a combination of potent plant actives sourced from the land and the sea—in order to create one-step topical skin care solutions to replace aesthetic procedures. Designed to achieve total skin health and youthful vitality by boosting skin longevity, repairing environmental damage, providing powerful antioxidant support, and fortifying the moisture barrier, of the over 50 organic actives in each product, many are discovered on Dr. Macrene's organic farm.