The Edit with 111SKIN
Meet Dr. Yannis Alexandrides, founder of 111SKIN and creator of the revolutionary Exosome Face Lift Protocol. In this exclusive Q&A, he explains what exosomes are, how they work, and why they represent one of the most exciting frontiers in skincare innovation.
1. We keep hearing about “exosomes” in skincare – what are they, and why are they such a big deal?
Exosomes are tiny messengers that our cells naturally use to communicate with one another. In the skin, they deliver vital signals that trigger repair and rejuvenation. In regenerative medicine, they represent a groundbreaking advancement for their remarkable ability to accelerate healing and renewal.
When we introduced exosomes into our treatments at 111 Harley St., my patients and I were amazed by the transformative results they experienced, which inspired me to develop the Exosomes Face Lift Protocol—bringing exosomes from the clinic to the cabinet. We use bacterial exosomes derived from probiotic strains, which enhance cell-to-cell communication by delivering proteins and growth factors that boost repair, collagen production, and cell turnover for smoother, firmer skin. For me, exosomes represent one of the most exciting frontiers in anti-aging innovation.
2. What makes the Exosome Face Lift Protocol different from a regular facial?
The Exosome Face Lift Protocol brings cutting-edge regenerative science into the comfort of your own home. This two-step protocol pairs the Exosome Shot Serum with an Overnight Mask—a powerful duo that stimulates collagen production while visibly lifting and firming the skin.
What truly sets it apart is the innovative delivery system I developed using microspicules—tiny, needle-like structures derived from a freshwater sponge. These create microchannels in the skin, mimicking microneedling, to allow the exosomes and actives to penetrate more deeply and trigger a regenerative response at the cellular level.
Unlike a traditional facial, which typically requires monthly sessions, the potency and efficacy of the Exosome Face Lift Protocol mean it only needs to be used two to three times per year. Over the course of four weeks, it delivers noticeable lifting, firming, and repair that go well beyond surface-level results.
3. How soon after the first treatment will we start to see results?
Many clients experience an immediate tightening effect, which can be attributed to additional active ingredients, including Swiss Ice Wine extract—a potent ingredient renowned for its instant firming properties.
Optimal results can be seen after four weeks of consistent use in your evening skincare routine, as the bacterial exosomes work to optimize cellular turnover and support deeper skin regeneration. In clinical trials, participants achieved up to a 20 percent visible lift and a 23 percent increase in firmness after just four weeks.* It is both fast-acting and progressive, requiring consistency to unlock its full regenerative potential.
4. Is this treatment suited for all skin types and ages?
We specifically formulated the Exosome Face Lift Protocol to deliver maximum efficacy with minimal irritation. By utilizing bacterial exosomes derived from advanced probiotic strains, the treatment avoids the allergenic concerns often associated with animal- or human-derived exosomes.
This ensures the formula is suitable for all skin types, including sensitive skin, and is ideal for those looking to address both early and more advanced signs of aging.
5. What’s your favorite part of the Exosome Face Lift Protocol experience?
Applying the Exosome Face Lift Protocol is a truly luxurious experience. Both the serum and mask feature a lightweight, velvety texture that glides effortlessly onto the skin, delivering an immediate tingling sensation—the true indication that the microspicules and actives are beginning to work!
However, the most rewarding part of the protocol is witnessing the visible lifting and firming results after four weeks.
6. Any tips for keeping that post-treatment glow going at home?
Following the protocol, I recommend maintaining a consistent skincare routine that supports cellular repair and prolongs visible results. A key product in this routine is the Black Diamond Serum, a gravity-defying formula that works to sculpt, firm, and rejuvenate the skin for a more youthful appearance. Powered by potent Microalgae Extract, it helps counteract laxity caused by collagen breakdown, delivering a lifted, tightened effect.
To further maintain results between treatments, the Wrinkle Erasing Retinol Patches offer a targeted, needle-free solution for fine lines and wrinkles. These precision patches use cutting-edge microcone technology, clinically proven to deliver twice the absorption speed and depth of actives compared to traditional topical formulas. Upon contact with the skin’s moisture, the microcones dissolve, delivering a potent blend of Retinol, Vitamin C, and a powerful peptide complex directly into the skin—precisely where it’s needed most.
This targeted at-home treatment is one I often recommend to my clients at 111 Harley St., particularly those looking to maintain their results between injectable treatments.
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